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Antigenic Specificity | Catenin, beta (p120) |
Clone | [6F9] |
Host Species | Mouse |
Reactive Species | human, cow, dog, chicken. |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAb recognizes a protein of 92kDa, which is identified as beta-catenin. It shows no cross-reaction with gamma-catenin (also known as plakoglobin). The catenins, alpha, beta and gamma bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. Alpha-catenin was initially described as an E-cadherin-associated protein, and has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. Beta-catenin has also been found in complexes with the tumor supp |
Immunogen | Immunogen: Recombinant chicken ?-catenin. Cellular Localization: Cell Surface and Cytoplasmic |
Other Names | [Cadherin associated protein; beta 1 88kDa; Catenin beta-1; CATNB; CHBCAT; CTNNB1], [CTNNB1; CTNNB1; EVR7; CTNNB; MRD19; armadillo; CTNNB] |
Gene, Accession # | [CTNNB1], Gene ID: 1499, NCBI: NP_001091679.1, UniProt: P35222 |
Catalog # | MBS439898 |
Price | $190, $340, $340 |
Order / More Info | Catenin, beta (p120) Antibody from MYBIOSOURCE INC. |
Product Specific References | Knudsen KA, Soler AP, Johnson KR, Wheelock MJ. Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. J Cell Biol. 1995; 130(1): 67-77. Sacco, PA; McGranahan TM; Wheelock, MJ; Johnson, KR. Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem 1995, 270: 20201-6. |