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Antigenic Specificity | GZMA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 29-262 of human GZMA (NP 006135.1). |
Other Names | [HFSP; CTLA3] |
Gene, Accession # | [GZMA], Gene ID: 3001, NCBI: NP_006135.1, UniProt: P12544 |
Catalog # | MBS8545961 |
Price | $280 |
Order / More Info | GZMA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |