SHANK3 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-SHANK3 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | SHANK3 |
| Clone | [S69-46] |
| Host Species | Mouse |
| Reactive Species | mouse, human, rat |
| Isotype | IgG2b |
| Format | ATTO 565 conjugate |
| Size | 0.1 mg |
| Concentration | 1mg/mL |
| Applications | Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background Info: Detects ~190kDa. No cross-reactivity against Shank1 or Shank2. Scientific Background: Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (3). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (4). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (5). |
| Immunogen | n/a |
| Other Names | [Shank3; Prosap2], [Shank3; Shank3; Prosap2; Prosap2; Shank3; ProSAP2] |
| Gene, Accession # | Gene ID: 59312, NCBI: NP_067708.1, UniProt: Q9JLU4 |
| Catalog # | MBS800137 |
| Price | $440 |
| Order / More Info | SHANK3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856. 4. Schuetz G., et al. (2004) JCB. 167(5): 645-952. 5. Durand C.M., et al. (2007) Nature Genetics. 39: 25-27. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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