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Antigenic Specificity | AFAP1L2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | AFAP1L2 Antibody: AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyr |
Immunogen | Immunogen: AFAP1L2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human AFAP1L2. Buffer: AFAP1L2 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [AFAP1L2; XB130; KIAA1914; CTB-1144G6.4; XB130; Actin filament-associated protein 1-like 2; AFAP1-like protein 2; actin filament associated protein 1-like 2], [AFAP1L2; AFAP1L2; XB130; KIAA1914; CTB-1144G6.4; KIAA1914; XB130; AFAP1-like protein 2] |
Gene, Accession # | [AFAP1L2], Gene ID: 84632, NCBI: NP_001001936, UniProt: Q8N4X5 |
Catalog # | MBS150382 |
Price | $375 |
Order / More Info | AFAP1L2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |