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Antigenic Specificity | EIF2AK2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human Eif2ak2 (NP 002750.1). |
Other Names | [PKR; PRKR; EIF2AK1; PPP1R83] |
Gene, Accession # | [EIF2AK2], Gene ID: 5610, NCBI: NP_001129123.1, UniProt: P19525 |
Catalog # | MBS8545659 |
Price | $280 |
Order / More Info | EIF2AK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |