Edit |   |
---|---|
Antigenic Specificity | HP1 alpha |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. |
Immunogen | Immunogen: A synthesized peptide derived from human HP1 alpha. Subcellular Localization: Nucleus. Chromosome. Chromosome, centromere. Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. |
Other Names | [Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha; CBX5; HP1A], [CBX5; CBX5; HP1; HP1A; HEL25; HP1A; HP1 alpha] |
Gene, Accession # | [CBX5], Gene ID: 23468, NCBI: NP_001120793.1, UniProt: P45973 |
Catalog # | MBS179889 |
Price | $160, $340, $340 |
Order / More Info | HP1 alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |