Edit |   |
---|---|
Antigenic Specificity | CD59 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | 0.02 mL, 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, ha |
Immunogen | Source Note: This monoclonal antibody is produced by immunizing animals with a polypeptide corresponding to CD59 protein. |
Other Names | [CD59 glycoprotein], [CD59; MIC11; MIN1; MIN2; MIN3; MSK21] |
Gene, Accession # | [CD59], Gene ID: 966, NCBI: NP_000602.1, UniProt: P13987 |
Catalog # | MBS435198 |
Price | $225, $350, $565 |
Order / More Info | CD59 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |