Edit |   |
---|---|
Antigenic Specificity | CREB |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody only recognizes ~40 kDa of human CREB protein. It also reacts with rat CREB protein. The other species are not tested. CREB is a bZIP transcription factor that binds the cAMP response element (CRE) and activates target genes. It is involved in many extracellular signals resulting in regulation of a variety of cellular responses. Phosphorylation of CREB at Ser133 by various kinases such as PKA, PKC, CaM kinase II and IV is necessary for CREB signaling. |
Immunogen | Antigen Preparation: A synthetic peptide corresponding to the epitope of RPSYR with a single phosphorylation site Ser133. |
Other Names | [Rabbit CREB; cAMP-response-element-binding protein (CREB).], [CREB1; CREB1; CREB; MGC9284] |
Gene, Accession # | [CREB], Gene ID: 1385, NCBI: P16220.2, UniProt: P16220 |
Catalog # | MBS462040 |
Price | $285 |
Order / More Info | CREB Antibody from MYBIOSOURCE INC. |
Product Specific References | Dong Ya Zhu, et al. Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus. PNAS, vol. 101 (25), 9453-9457 (2004) |