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Antigenic Specificity | Human MIS |
Clone | [7H26] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MuI?llerian inhibiting substance (MIS), also named antiMuI?llerian hormone (AMH), is a tissuespecific TGFbeta superfamily growth factor. Its expression is restricted to the Sertoli cells of fetal and postnatal testis, and to the granulosa cells of postnatal ovary. The human MIS gene encodes a 553 amino acid residue (aa) prepropeptide containing a signal a sequence (1-24), a proregion (25-455), and the carboxylterminal bioactive protein (446-553). MIS is synthesized and secreted as a disulfidelinked homodimeric proprotein. Proteolytic cleavage is required to generate the Nterminal pro region and the C-terminal bioactive protein, which remain associated in a noncovalent complex. Recombinant C-terminal MIS has been shown to be bioactive. Howev |
Immunogen | Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of MIS. |
Other Names | [AMH; MIF; MIS], [AMH; AMH; MIF; MIS; MIF; AMH; MIS] |
Gene, Accession # | [MIS], Gene ID: 268, NCBI: NP_000470.2, UniProt: P03971 |
Catalog # | MBS690011 |
Price | $490 |
Order / More Info | Human MIS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |