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Antigenic Specificity | Keratin 17 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit polyclonal to Keratin 17. Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as biomarkers (1). Mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6). Keratin 17 is involved in wound healing and cell growth, two processes that require rapid cytoskeletal remodeling (7). Keratinocytes deficient in keratin 17 exhibit abnormal Ak |
Immunogen | Immunogen: A synthetic -peptide of human Keratin 17 |
Other Names | [KRT17; Keratin 17; Keratin 17; RT17; K17; PC; PC2; PCHC1], [KRT17; KRT17; PC; K17; PC2; PCHC1; CK-17; K17] |
Gene, Accession # | Gene ID: 3872, NCBI: NP_000413.1, UniProt: Q04695 |
Catalog # | MBS125073 |
Price | $200, $275, $430 |
Order / More Info | Keratin 17 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Moll, R. et al. (1982) Cell 31, 11-24. 2. Chang, L. and Goldman, R.D. (2004) Nat Rev Mol Cell Biol 5, 601-13. 3. Ramaekers, F.C. and Bosman, F.T. (2004) J Pathol 204, 351-4. 4. Lane, E.B. and McLean, W.H. (2004) J Pathol 204, 355-66. 5. Zatloukal, K. et al. (2004) J Pathol 204, 367-76. 6. Owens, D.W. and Lane, E.B. (2004) J Pathol 204, 377-85. 7. Paladini, R.D. et al. (1996) J. Cell Biol. 132, 381-397. |