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Antigenic Specificity | SUV4-20H2 (Center), 4-20 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse (predicted reactivity: rat) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This SUV4-20H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-214 amino acids from the Central region of human SUV4-20H2. SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). |
Immunogen | n/a |
Other Names | [Histone-lysine N-methyltransferase SUV420H2; Lysine N-methyltransferase 5C; Suppressor of variegation 4-20 homolog 2; Su(var)4-20 homolog 2; Suv4-20h2; SUV420H2; KMT5C] |
Gene, Accession # | [SUV420H2], Gene ID: 84787, NCBI: NP_116090.2, UniProt: Q86Y97 |
Catalog # | MBS9209272 |
Price | $165, $370 |
Order / More Info | SUV4-20H2 (Center), 4-20 Antibody from MYBIOSOURCE INC. |
Product Specific References | Souza,P.P., BMC Cell Biol. 10, 41 (2009) Tryndyak,V.P., Cancer Biol. Ther. 5 (1), 65-70 (2006) |