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Antigenic Specificity | CSK (Center) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This CSK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 164-197 amino acids from the Central region of human CSK. Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near |
Immunogen | n/a |
Other Names | [Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL; CSK] |
Gene, Accession # | [CSK], Gene ID: 1445, NCBI: NP_001120662.1, UniProt: P41240 |
Catalog # | MBS9207906 |
Price | $165, $370 |
Order / More Info | CSK (Center) Antibody from MYBIOSOURCE INC. |
Product Specific References | Partanen J.,et al.Oncogene 6:2013-2018(1991). Braeuninger A.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:10411-10415(1991). Brauninger A.,et al.Gene 110:205-211(1992). Braeuninger A.,et al.Oncogene 8:1365-1369(1993). Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. |