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Antigenic Specificity | Akt1 |
Clone | [2D9-D2-H3] |
Host Species | Mouse |
Reactive Species | mouse, Transfected |
Isotype | IgG2a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | 15mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Entrez Summary: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in |
Immunogen | Immunogen: Purified recombinant human AKT1 protein fragments expressed in E Coli. Sensitivity: This antibody detects endogenous levels of AKT1 and does not cross-react with AKT2 and other proteins. Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 PH domain. Contains 1 protein kinase domain. |
Other Names | [AKT 1; AKT; AKT1; AKT1_HUMAN; C AKT; MGC99656; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC; RAC PK Alpha; RAC Serine/Threonine Protein Kinase; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; vAKT Murine Thymoma Viral Oncogene Homolog 1], [AKT1; AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA] |
Gene, Accession # | [Akt1], Gene ID: 207, NCBI: NP_001014431.1, UniProt: P31749 |
Catalog # | MBS475186 |
Price | $335 |
Order / More Info | Akt1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |