GRK4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | GRK4 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: GRK4 antibody detects endogenous levels of total GRK4. Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.Subunit Structure: Interacts with DRD3.Post-translational Modifications: Palmitoylated.Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. |
| Immunogen | Immunogen: A synthesized peptide Subcellular Location: Cytoplasm. Cytoplasm > Cell Cortex. Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where co-localization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. Tissue Specificity: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isofo |
| Other Names | [G protein coupled receptor kinase 4; G protein-coupled receptor kinase 2 (Drosophila)-like; G protein-coupled receptor kinase 4; G protein-coupled receptor kinase GRK4; G proteinm coupled receptor kinase GRK4; GPRK2L; GPRK4; GRK4; GRK4_HUMAN; GRK4a; ITI1] |
| Gene, Accession # | [GRK4], Gene ID: 2868, NCBI: NP_001004056.1, UniProt: P32298 |
| Catalog # | MBS9604615 |
| Price | $240, $280 |
| Order / More Info | GRK4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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