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Antigenic Specificity | IRF3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells. Following viral infection, IRF3 can be activated by IkB kinase-eta and TANK-binding kinase 1 (TBK1), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA. IRF3 exists as at least two distinct isoforms. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human IRF3. |
Other Names | [interferon regulatory factor 3 isoform 1; Interferon regulatory factor 3; interferon regulatory factor 3; interferon regulatory factor 3] |
Gene, Accession # | [IRF3], Gene ID: 3661, NCBI: NP_001562 |
Catalog # | MBS9408445 |
Price | $320 |
Order / More Info | IRF3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |