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Antigenic Specificity | FAM175A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.8mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total FAM175A protein. Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
Immunogen | Immunogen: Full length fusion protein of human FAM175A Immunogen Type: Peptide |
Other Names | [ABRA1; CCDC98] |
Gene, Accession # | [FAM175A], Gene ID: 84142, NCBI: BC016905, UniProt: Q6UWZ7 |
Catalog # | MBS9429710 |
Price | $255 |
Order / More Info | FAM175A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |