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Antigenic Specificity | Mouse SERPINA6 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | IgG |
Format | unconjugated |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. T |
Immunogen | Immunogen: Recombinant Mouse SerpinA6 protein Buffer: 0.2 mum filtered solution in PBS with 5% trehalose |
Other Names | [SERPINA6, partial; Corticosteroid-binding globulin; corticosteroid-binding globulin; serpin family A member 6; Serpin A6; Transcortin] |
Gene, Accession # | [SERPINA6 ], Gene ID: 866 |
Catalog # | MBS2544547 |
Price | $215, $330, $500 |
Order / More Info | Mouse SERPINA6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |