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Antigenic Specificity | DTX4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA,IF, IHC-P, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist; this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members. The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1). Recent studies have shown that DTX4 is also associated with the innate immune response (2). Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2). |
Immunogen | Immunogen: DTX4 antibody was raised against a 19 amino acid peptide near the center of human DTX4. The immunogen is located within amino acids 230 - 280 of DTX4. Buffer: DTX4 antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [Deltex 4 E3 ubiquitin ligase; RNF155; deltex 4, E3 ubiquitin ligase], [DTX4; DTX4; RNF155; KIAA0937; RNF155; Deltex4] |
Gene, Accession # | [DTX4], Gene ID: 23220, NCBI: NP_055992, UniProt: Q9Y2E6 |
Catalog # | MBS153511 |
Price | $375 |
Order / More Info | DTX4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |