TIGIT [7E5] Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | TIGIT [7E5] |
| Clone | [7E5] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b |
| Format | Protein A purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2). |
| Immunogen | Immunogen: TIGIT antibody was raised against the extracellular domain of human TIGIT. Conjugate: Unconjugated |
| Other Names | [T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; WUCAM], [TIGIT; TIGIT; VSIG9; VSTM3; WUCAM; VSIG9; VSTM3] |
| Gene, Accession # | [TIGIT], Gene ID: 201633, NCBI: NP_776160, UniProt: Q495A1 |
| Catalog # | MBS154588 |
| Price | $440 |
| Order / More Info | TIGIT [7E5] Antibody from MYBIOSOURCE INC. |
| Product Specific References | Stanietsky N, Simic H, Arapovic J, et al. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc Natl Acad Sci USA 2009; 106:17858-63. Johnston RJ, Comps-Agrar L, Hackney J, et al. The immunoreceptor TIGIT regulates antitumor and antiviral CD8( ) T cell effector function. Cancer Cell 2014; 26:923-37. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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