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Antigenic Specificity | PAR4 |
Clone | polyclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor |
Immunogen | Immunogen: Purified recombinant fragment of PAR4(aa1-330) expressed in E. Coli. |
Other Names | [PAWR], [PAWR; PAWR; PAR4; Par-4; PAR4; Par-4] |
Gene, Accession # | [PAR4], Gene ID: 5074, NCBI: NP_002574.2, UniProt: Q96IZ0 |
Catalog # | MBS850478 |
Price | $280 |
Order / More Info | PAR4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |