Edit |   |
---|---|
Antigenic Specificity | ALS2 |
Clone | monoclonal |
Host Species | n/a |
Reactive Species | mouse. Not tested in other organisms |
Isotype | IgG1 kappa |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 100ug/100ul |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. |
Immunogen | Immunogen: Recombinant fragment: PSQDLKPVPE RCNQCSQLLI TMTDKEDHVI ISDSHCCPLG VTLTESQAEN HASTALSPST ETLDRQEEVF ENTLVANDQS VATELNAVSA QITSSDAMSS, corresponding to amino acids 221-321 of Human Als2 |
Other Names | [Homo sapiens amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 2, mRNA; Alsin; alsin; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; amyotrophic lateral sclerosis 2 protein; amyotrophic lateral sclerosis 2 (juvenile); Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; Amyotrophic lateral sclerosis 2 protein], [ALS2; ALS2; ALSJ; PLSJ; IAHSP; ALS2CR6] |
Gene, Accession # | [ALS2], Gene ID: 57679, NCBI: NP_001129217.1 |
Catalog # | MBS415333 |
Price | $330 |
Order / More Info | ALS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |