PTGS2 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | PTGS2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | humans, catalyze prostaglandin production from arachidonic acid (1,2). While Cox1 expression is constitutive in most tissues, Cox2 expression is induced by lipopolysaccharide (LPS) and peptidoglycan (PGN) (3). PGN activates Ras, leading to phosphorylation of Raf at Ser338 and Erk1/2 at Tyr204. The activation of MAP kinase signaling results in subsequent activation of IKKalpha/beta, phosphorylation of IkappaBalpha at Ser32/36, and NFkappaB activation. Finally, activation of the transcription factor NFkappaB is responsible for the induction of Cox2 expression (4). Investigators have shown that LPS and PGN induce the clinical manifestations of arthritis and bacterial infections, such as inflammation, fever, and septic shock (5). Research studi |
| Immunogen | Immunogen: A synthetic peptide of human PTGS2 |
| Other Names | [PTGS2; COX2; PTGS2; COX2; Prostaglandin G/H synthase 2; Cyclooxygenase2; PHS II; Prostaglandin H2 synthase 2; Prostaglandinendoperoxide synthase 2;], [PTGS2; PTGS2; COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS; COX2; COX-2; PGH synthase 2; PGHS-2] |
| Gene, Accession # | Gene ID: 5743, NCBI: NP_000954.1, UniProt: P35354 |
| Catalog # | MBS127147 |
| Price | $275, $430 |
| Order / More Info | PTGS2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Xie, W.L. et al. (1991) Proc Natl Acad Sci USA 88, 2692-6. 2. Vane, J.R. et al. (1998) Annu Rev Pharmacol Toxicol 38, 97-120. 3. O'Neill, G.P. et al. (1994) Mol Pharmacol 45, 245-54. 4. Chen, B.C. et al. (2004) J Biol Chem 279, 20889-97. 5. Wang, Q. et al. (2001) Infect Immun 69, 2270-6. 6. Qin, W. et al. (2003) J Biol Chem 278, 50970-7. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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