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Antigenic Specificity | SHANK2 |
Clone | [S23b-6] |
Host Species | Mouse |
Reactive Species | mouse (weak), human, rat |
Isotype | IgG1 |
Format | phycoerythrin (RPE) conjugate |
Size | 0.1 mg |
Concentration | 1mg/mL |
Applications | Western (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background Info: Detects ~160kDa. No cross-reactivity against Shank1 or Shank3. Scientific Background: Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (3). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (4). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfuncti |
Immunogen | n/a |
Other Names | [Shank2; PROSAP1; cortactin binding protein 1; KIAA1022; AUTS17; CortBP1; Proline-rich synapse-associated protein 1; SH3 and multiple ankyrin repeat domains protein 2; Cortactin-binding protein 1; proline-rich synapse associated protein 1; SPANK-3], [Shank2; Shank2; CortBP1; ProSAP1; Spank-3; Cortbp1; Shank2; CortBP1; ProSAP1] |
Gene, Accession # | Gene ID: 171093, NCBI: NP_958738.1, UniProt: Q9QX74 |
Catalog # | MBS800052 |
Price | $435 |
Order / More Info | SHANK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Sheng M., and Kim E. (2000) Journal of Cell Science. 113: 1851-1856. 4. Kim J.H., et al. (2009) Exp Mol Med. 41(4): 236-242. 5. Gong Y., et al. (2009) Brain Res. 1292: 191-198. |