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Antigenic Specificity | Ring1A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total Ring1A protein. Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compare |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.35~39(I-A-V-S-P) derived from Human Ring1A. |
Other Names | [RNF1; RING1] |
Gene, Accession # | [Ring1A], Gene ID: 6015, NCBI: NP_002922.2, UniProt: Q06587 |
Catalog # | MBS9411536 |
Price | $200, $255 |
Order / More Info | Ring1A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |