Edit |   |
---|---|
Antigenic Specificity | Unc93b |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Multiple isoforms of Unc93b are known to exist. This antibody will not cross-react with Unc93a. Unc93b Antibody: The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indica |
Immunogen | Immunogen: Unc93b antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human Unc93b. Buffer: Unc93b Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [Unc93b; IIAE1; UNC93; UNC93B; Unc-93B1; Protein unc-93 homolog B1; unc-93 homolog B1 (C. elegans)], [UNC93B1; UNC93B1; IIAE1; UNC93; UNC93B; Unc-93B1; UNC93; UNC93B; Unc-93B1; hUNC93B1] |
Gene, Accession # | [UNC93B1], Gene ID: 81622, NCBI: AAH33623, UniProt: Q9H1C4 |
Catalog # | MBS150832 |
Price | $375 |
Order / More Info | Unc93b Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |