Human FADD-SEPH Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human FADD-SEPH |
| Clone | [1A11] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 50 tests |
| Concentration | n/a |
| Applications | ELISA; Immunoprecipitation; Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Human FADD. Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1 beta -converting enzyme. FADD has also been shown under |
| Immunogen | n/a |
| Other Names | [Mouse Human FADD - Sepharose-Labeled; Mouse Human FADD], [fadd] |
| Gene, Accession # | Gene ID: 100368353 |
| Catalog # | MBS670128 |
| Price | $435 |
| Order / More Info | Human FADD-SEPH Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Chinnaiyan, A.M., K. O'Rourke, M. Tewari, and V.M. Dixit. 1995. Cel. 81:505.2. Cleveland, J.L., and J.N. Ihle. 1995. Cell 81:479.3. Muzio, M., A.M. Chinnaiyan, F.C. Kishkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J.D. Bretz, M. Zhang, R. Gentz, M. Mann, P.H. Krammer, M.E. Peter, and V.M. Dixit. 1996. Cell 85:817.4. Wieder, T., F. Essmann, A. Prokop, K. Schmelz, K. Schulze-Osthoff, R. Beyaert, B. Dorken, and P.T. Daniel. 2001. Blood 97:1378.5. Newton, K., A.W. Harris, M.L. Bath, K.G.C. Smith, and A. Strasser. 1998. EMBO J. 17:706.6. Boldin, M.P., E.E. Varfolomeev, Z. Pancer, I.L. Meet, J.H. Camonis, and D. Wallach. 1995. J. Biol. Chem. 270:7795. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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