HDAC1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHDAC1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
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DescriptionAcetylation of the histone tail causes chromatin to adopt an open conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription (1, 2). HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes (3). In contrast, histone deacetylation promotes a closed chromatin conformation and typically leads to repression of gene activity (4). Mammalian histone deacetylases can be divided into three classes on the basis of th
ImmunogenImmunogen: N term-peptide of human HDAC1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Names[HDAC1; DKFZp686H12203; GON-10; HD1; RPD3; RPD3L1]
Gene, Accession #[HDAC1], Gene ID: 3065, NCBI: NP_004955.2, UniProt: Q13547
Catalog #MBS8505084
Price$310
Order / More InfoHDAC1 Antibody from MYBIOSOURCE INC.
Product Specific References1. Marmorstein, R. (2001) Cell Mol Life Sci 58, 693-703. 2. Gregory, P.D. et al. (2001) Exp Cell Res 265, 195-202. 3. Liu, Y. et al. (2000) Mol Cell Biol 20, 5540-53. 4. Cress, W.D. and Seto, E. (2000) J Cell Physiol 184, 1-16. 5. Gray, S.G. and Ekstrom, T.J. (2001) Exp Cell Res 262, 75-83. 6. Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100. 7. Vigushin, D.M. and Coombes, R.C. (2004) Curr. Cancer Drug Targets 4, 205-218.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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