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Antigenic Specificity | HAAO |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders asso |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 17 amino acid peptide near the amino terminus of human HAAO. |
Other Names | [3-hydroxyanthranilate 3, 4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HAO, HAD, HAO] |
Gene, Accession # | [HAAO], Gene ID: 23498, NCBI: NP_036337 |
Catalog # | MBS9406597 |
Price | $320 |
Order / More Info | HAAO Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |