CDC25A Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-CDC25A antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | CDC25A |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The cdc25 protein phosphatase family plays a critical role in activating cyclin-dependent kinases (CDKs) via dephosphorylation of conserved Thr14/Tyr15 inhibitory phosphorylation sites. While cdc25C is primarily responsible for activating CDK1 to overcome the G2/M checkpoint and allow mitotic entry, the primary substrate of cdc25A is CDK2, which, when active, allows progression through the G1/S and intra-S checkpoints (1). Abundance, subcellular localization and activity of cdc25A is tightly controlled by a variety of mechanisms, including phosphorylation, ubiquitination, and inhibitory binding to 14-3-3 proteins. During normal cell cycle progression, elevated c-Myc and E2F transcription factor levels lead to increased cdc25A expression (2) |
| Immunogen | Immunogen: Recombinant protein of human CDC25A Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [CDC25A2; CDC25A; cdc25A] |
| Gene, Accession # | [CDC25A], Gene ID: 993, NCBI: NP_001780.2, UniProt: P30304 |
| Catalog # | MBS8505886 |
| Price | $310 |
| Order / More Info | CDC25A Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Hoffmann, I. et al. (1994) EMBO J. 13, 4302-4310. 2. Vigo, E. et al. (1999) Mol. Cell. Biol. 19, 6379-6395. 3. Chen, M. et al. (2003) Mol. Cell. Biol. 23, 7488-7497. 4. Sorensen, C.S. et al. (2003) Cancer Cell 3, 247-258. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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