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Antigenic Specificity | TNF Receptor-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total TNF receptor-1 protein. Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.Jennifer Adjodha, AACR Meeting Abstracts, Apr 2006; 2006: 1028. Kewu Huang, J Appl Physiol, Apr 2007; 102: 1632 - 1639. Kiyoshi Asada, AACR Meeting Abstracts, Apr 2005; 2005: 202. Elaine K Green, |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from Internal of human TNF receptor-1. |
Other Names | [CD120a; TBPI; TNF-RI; TNFAR; TNFR1] |
Gene, Accession # | [TNF], Gene ID: 7132, NCBI: NP_001056.1, UniProt: P19438 |
Catalog # | MBS9413548 |
Price | $200, $255 |
Order / More Info | TNF Receptor-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |