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Antigenic Specificity | RIPK2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is rel |
Immunogen | Immunogen: Recombinant human Receptor-interacting serine/threonine-protein kinase 2 protein (1-540aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8611 / sc-8610 / sc-22763 |
Other Names | [Receptor-interacting serine/threonine-protein kinase 2; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2; RIPK2; CARDIAK; RICK; RIP2], [RIPK2; RIPK2; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; CARDIAK; RICK; RIP2; CARD-containing IL-1 beta ICE-kinase; RIP-2] |
Gene, Accession # | [RIPK2], Gene ID: 8767, NCBI: NP_003812.1, UniProt: O43353 |
Catalog # | MBS1498186 |
Price | $120, $160 |
Order / More Info | RIPK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |