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Antigenic Specificity | KRIT1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this |
Immunogen | Immunogen: Recombinant protein of human KRIT1 (NP 919438.1). |
Other Names | [krev interaction trapped protein 1 isoform 2; Krev interaction trapped protein 1; krev interaction trapped protein 1; KRIT1 ankyrin repeat containing; Cerebral cavernous malformations 1 protein] |
Gene, Accession # | [KRIT1], Gene ID: 889, NCBI: NP_001013424.1, UniProt: O00522 |
Catalog # | MBS8571016 |
Price | $280 |
Order / More Info | KRIT1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |