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Antigenic Specificity | Nestin |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | affinity purified |
Size | 0.1 mL |
Concentration | 100ug/100ul |
Applications | Immunoblot (IB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Nestin is a Nestin is an intermediate filament protein that was first identified with a monoclonal antibody by Hockfield and McKay (1985). It is expressed predominantly in stem cells of the central nervous system in the neural tube. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments. |
Immunogen | Immunogen: Nestin is a member of the class IV intermediate filament protein family which is expressed in neuronal stem cells, which is the origin of the name nestin (1). Nestin was originally identified as a result of the production of a series of monoclonal antibodies directed against epitopes expressed on formalin fixed embyro day 15 rat spinal cord (2). One of these antibodies, called Rat 401, stained fibrous profiles in the developing nervous system, but not in the mature nervous system. By |
Other Names | [Nestin], [NES; NES; Nbla00170] |
Gene, Accession # | Gene ID: 10763, NCBI: NP_006608.1, UniProt: P48681 |
Catalog # | MBS415113 |
Price | $370 |
Order / More Info | Nestin Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Lendahl U, Zimmerman LB and McKay RD. CNS stem cells express a new class of intermediate filament protein. Cell 60:585-95 (1990).2. Hockfield S and McKay RD. Identification of major cell classes in the developing mammalian nervous system. J. Neurosci. 5:3310-3328 (1985). |