Phospho-mTOR (Ser2481) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-mTOR (Ser2481) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-mTOR (Ser2481) antibody detects endogenous levels of mTOR only when phosphorylated at Serine 2481. Description: An atypical kinase belonging to the PIKK family of kinases. Controls cell growth through protein synthesis regulation. Downstream of PI3K/Akt pathway and required for cell survival. Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.Function: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functi |
| Immunogen | Immunogen: A synthesized peptide derived from human mTOR around the phosphorylation site of Serine 2481 Subcellular Location: Endoplasmic Reticulum Membrane. Golgi Apparatus Membrane. Mitochondrion Outer Membrane. Lysosome. Cytoplasm. Nucleus > PML Body. Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB. Tissue Specificity: Expressed in numerous tissues, with hig |
| Other Names | [dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1); FK506 binding protein 12 rapamycin associated protein 1; FK506 binding protein 12 rapamycin associated protein 2; FK506 binding protein 12 rapamycin complex associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP rapamycin associated protein; FKBP12 rapamycin complex associated protein; FKBP12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; FLJ44809; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; Mechanistic target of rapamycin; mTOR; MTOR_HUMAN; OTTHUMP00000001983; RAFT1; Rapamycin and FKBP12 target 1; Rapamycin associated protein FRAP2; Rapamycin target protein 1; Rapamycin target protein; RAPT1; Serine/threonine-protein kinase mTOR] |
| Gene, Accession # | [mTOR], Gene ID: 2475, NCBI: NP_004949.1, UniProt: P42345 |
| Catalog # | MBS9601078 |
| Price | $240, $280 |
| Order / More Info | Phospho-mTOR (Ser2481) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Zhao ZH, Deng B, Xu H, Zhang JF, Mi YJ, Meng XZ, Gou XC, Xu LX; Journal: Cell Mol Neurobiol. PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury. Juan Ji Teng, Fei Xue Xu, Dong Guo Jin Yang Ruo, Bing Guo Juan Wang Ji, Ye Huang Xiao, Jie Zhao Xiu, Lan Sun; Journal: Aging Cell. Antagonizing peroxisome proliferator activated receptor facilitates M1 to M2 shift of microglia by enhancing autophagy via the LKB 1-AMPK signaling pathway. |
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MYBIOSOURCE INC.
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