HDAC4/Histone Deacetylase 4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | HDAC4/Histone Deacetylase 4 |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.03 mg, 0.1 mg, 0.1 mg |
| Concentration | n/a |
| Applications | Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
| Immunogen | Immunogen: A synthesized peptide derived from human HDAC4. Subcellular Localization: Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probab |
| Other Names | [Histone deacetylase 4; HD4; 3.5.1.98; HDAC4; KIAA0288], [HDAC4; HDAC4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; KIAA0288; HD4] |
| Gene, Accession # | [HDAC4], Gene ID: 9759, NCBI: NP_006028.2, UniProt: P56524 |
| Catalog # | MBS179509 |
| Price | $160, $340, $340 |
| Order / More Info | HDAC4/Histone Deacetylase 4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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