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Antigenic Specificity | Grap |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Grap Polyclonal Antibody detects endogenous levels of Grap protein. GRAP encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. |
Immunogen | Immunogen: Synthesized peptide derived from the N-terminal region of human Grap at AA rangle: 10-90 |
Other Names | [Rabbit Grap; GRB2-related adapter protein] |
Gene, Accession # | [GRAP], Gene ID: 10750, NCBI: NP_006604.1, UniProt: Q13588 |
Catalog # | MBS9704194 |
Price | $130, $220, $325 |
Order / More Info | Grap Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |