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Antigenic Specificity | ATP1A1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The Na, K-ATPase is an integral membrane heterodimer belonging to the P-type ATPase family. This ion channel uses the energy derived from ATP hydrolysis to maintain membrane potential by driving sodium export and potassium import across the plasma membrane against their electrochemical gradients. It is composed of a catalytic alpha subunit and a beta subunit (reviewed in 1). Several phosphorylation sites have been identified for the alpha1 subunit. Tyr10 is phosphorylated by an as yet undetermined kinase (2), Ser16 and Ser23 are phosphorylated by PKC, and Ser943 is phosphorylated by PKA (3-5). All of these sites have been implicated in the regulation of enzyme activity in response to hormones and neurotransmitters, altering trafficking and |
Immunogen | Immunogen: Fusion protein of human ATP1A1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [ATP1A1; MGC3285; MGC51750; Na; K-ATPase] |
Gene, Accession # | [ATP1A1], Gene ID: 476, NCBI: NP_000692.2, UniProt: P05023 |
Catalog # | MBS8527342 |
Price | $310 |
Order / More Info | ATP1A1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Therien, A.G. and Blostein, R. (2000) Am. J. Physiol. Cell Physiol. 279, C541-566. 2. Feraille, E. et al. (1999) Mol. Biol. Cell 10, 2847-2859. 3. Fisone, G. et al. (1994) J. Biol. Chem. 269, 9368-9373. 4. Feschenko, M.S. and Sweadner, K.J. (1995) J. Biol. Chem. 270, 14072-14077. 5. Beguin, P. et al. (1994) J. Biol. Chem. 269, 24437-24445. 6. Yingst, D.R. et al. (2004) Am. J. Physiol. Renal Physiol. 287, F713-F721. 7. Al-Khalili, L. et al. (2004) J. Biol. Chem. 279, 25211-25218. 8. Tian, J. et al. (2006) Mol. Biol. Cell 17, 317-326. 9. Liang, M. et al. (2006) J. Biol. Chem. 281, 19709-19719. |