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Antigenic Specificity | PRKCH |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | fluorescein (FITC) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with |
Immunogen | Immunogen: Recombinant human Protein kinase C eta type protein |
Other Names | [Protein kinase C eta type; PKC-L; nPKC-eta; PRKCH; PKCL; PRKCL] |
Gene, Accession # | [PRKCH], Gene ID: 5583, NCBI: NP_006246.2, UniProt: P24723 |
Catalog # | MBS7000012 |
Price | $160, $235 |
Order / More Info | PRKCH Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |