TAB1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityTAB1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatantigen affinity purified
Size0.1 mL
Concentration2.1 mg/ml
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionThe antibody detects endogenous levels of total TAB1 protein. The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.
ImmunogenImmunogen Type: Recombinant Protein Immunogen Description: Fusion protein corresponding to a region derived from internal residues of human TGF-beta activated kinase 1/MAP3K7 binding protein 1
Other Names[3'-Tab1; MAP3K7IP1]
Gene, Accession #[TAB1], Gene ID: 10454, NCBI: NP_006107.1, UniProt: Q15750
Catalog #MBS9408477
Price$255
Order / More InfoTAB1 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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