SOCS7 (C-term), 458-486 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SOCS7 (C-term), 458-486 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: mouse) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.35 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This SOCS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-486 amino acids from the C-terminal region of human SOCS7. Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarit |
| Immunogen | n/a |
| Other Names | [Suppressor of cytokine signaling 7; SOCS-7; Nck; Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4; SOCS7; NAP4; SOCS6] |
| Gene, Accession # | [SOCS7], Gene ID: 30837, NCBI: NP_055413.1, UniProt: O14512 |
| Catalog # | MBS9211441 |
| Price | $165, $370 |
| Order / More Info | SOCS7 (C-term), 458-486 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Pazienza, V., et al. J. Gen. Virol. 91 (PT 7), 1678-1686 (2010) : Sasi, W., et al. BMC Cancer 10, 178 (2010) : Kremer, B.E., et al. Cell 130(5):837-850(2007) Zody, M.C., et al. Nature 440(7087):1045-1049(2006) Banks, A.S., et al. J. Clin. Invest. 115(9):2462-2471(2005) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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