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Antigenic Specificity | SIAH2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination a |
Immunogen | Immunogen: Recombinant Human E3 ubiquitin-protein ligase SIAH2 protein (1-72AA) |
Other Names | [E3 ubiquitin-protein ligase SIAH2; RING-type E3 ubiquitin transferase SIAH2; Seven in absentia homolog 2; Siah-2; hSiah2; SIAH2] |
Gene, Accession # | [SIAH2], Gene ID: 6478, NCBI: NP_005058.3, UniProt: O43255 |
Catalog # | MBS7109012 |
Price | $160, $235 |
Order / More Info | SIAH2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |