Phospho-Ser459 Protein Tyrosine Phosphatase H1 (PTPH1) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Ser459 Protein Tyrosine Phosphatase H1 (PTPH1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for ~104k PTPH1 protein phosphorylated at Ser459. Immunolabeling is blocked by preadsorption of the antibody with the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Immunolabeling is also completely eliminated by treatment with lambda phosphatase. Affinity purified rabbit polyclonal antibody. Protein-tyrosine Phosphatase H1 (PTPH1) has recently been identified as a specific p38gamma MAPK phosphatase which is mediated through PDZ interaction (Hou et al., 2010). Ras has been demonstrated to increase both p38gamma and PTPH1 protein expression, and there is a coupling of increased p38gamma and PTPH1 protein expression in primary colon cancer tissues (Hou et al., 2010). Phosphorylation of PTPH |
| Immunogen | Antigen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser459 of human PTPH1. Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser459 conjugated to KLH. Immunogen Species: Human |
| Other Names | [tyrosine-protein phosphatase non-receptor type 3 isoform 2; Tyrosine-protein phosphatase non-receptor type 3; tyrosine-protein phosphatase non-receptor type 3; protein-tyrosine phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 3; Protein-tyrosine phosphatase H1], [PTPN3; PTPN3; PTPH1; PTP-H1; PTPH1; PTP-H1] |
| Gene, Accession # | [PTPH1], Gene ID: 5774, NCBI: NP_001138840.1, UniProt: P26045 |
| Catalog # | MBS502201 |
| Price | $360 |
| Order / More Info | Phospho-Ser459 Protein Tyrosine Phosphatase H1 (PTPH1) Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G (2010) PTPH1 Dephosphorylates and Cooperates with p38gamma MAPK to Increase Ras Oncogenesis through PDZ-Mediated Interation. Cancer Res 70:2901-2910.• Hou SW, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G (2012) p38gamma Mitogen-activated Protein Kinase Signals through Phosphorylating Its Phosphatase PTPH1 in Regulating Ras Protein Oncogenesis and Stress Response. J Biol Chem 287(33): 27895-905. |
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