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Antigenic Specificity | Human heparanase |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse; |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.15 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wo |
Immunogen | Immunogen: Human HPSE. Conjugate : Non-conjugated |
Other Names | [Endo-glucoronidase, Heparanase-1, HEP, HPA, HPA1, HPR1, HPSE1, HSE1, HPSE], [HPSE; HPSE; HPA; HPA1; HPR1; HSE1; HPSE1; HEP; HPA; HPA1; HPR1; HPSE1; HSE1; Hpa1] |
Gene, Accession # | Gene ID: 10855, NCBI: AAD54941.1 |
Catalog # | MBS711555 |
Price | $230, $500 |
Order / More Info | Human heparanase Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |