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Antigenic Specificity | ESR1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-ka |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human ESR1 (NP 000116.2). |
Other Names | [ER; ESR; Era; ESRA; ESTRR; NR3A1] |
Gene, Accession # | [ESR1], Gene ID: 2099, NCBI: NP_000116.2, UniProt: P03372 |
Catalog # | MBS8544010 |
Price | $280 |
Order / More Info | ESR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |