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Antigenic Specificity | P21 Mouse |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human, mouse, monkey. |
Isotype | IgG1 |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Please decide specifity by homology. CDKN1A (p21, CIP1, WAF1), a cyclin-dependent kinase inhibitor, is necessary for proper control of the cell cycle and premature senescence. P21 is a cyclin-dependent kinase (CDK) inhibitor that suppresses proliferation by inhibiting CDK2 and CDK1 activity at the G1/S and G2/M transitions. P21 is a major mediator of p53 to induce cell cycle arrest in G1. p21 can interact with proliferating cell nuclear antigen (PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. P21 was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. |
Immunogen | Immunogen: Cyclin-dependent kinase inhibitor 1A (p21, Cip1) Calculated MW: 21 kDa |
Other Names | [CAP20, CDK interacting protein 1, CDKN1, CDKN1A, CIP1, MDA 6, MDA6, P21, p21CIP1, PIC1, SDI1, WAF1] |
Gene, Accession # | [P21], Gene ID: 1026, NCBI: AAB29246.1, UniProt: P38936 |
Catalog # | MBS7602299 |
Price | $290 |
Order / More Info | P21 Mouse Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |