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Antigenic Specificity | CIB1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adh |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human CIB1 (NP 006375.2). |
Other Names | [CIB; CIBP; KIP1; PRKDCIP; SIP2-28] |
Gene, Accession # | [CIB1], NCBI: Q99828.4, UniProt: Q99828 |
Catalog # | MBS8545385 |
Price | $280 |
Order / More Info | CIB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |