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Antigenic Specificity | Human Caspase-3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | caprylic acid ammonium sulfate precipitate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Involved in the activation cascade of caspases responsible for apoptosis execution.This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer s disea |
Immunogen | Immunogen: Recombinant human Caspase-3 protein |
Other Names | [Apopain; Cysteine protease CPP32Protein Yama; SREBP cleavage activity 1] |
Gene, Accession # | [CASP3], Gene ID: 836, NCBI: NP_004337.2, UniProt: P42574 |
Catalog # | MBS7001270 |
Price | $160, $235 |
Order / More Info | Human Caspase-3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |