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Antigenic Specificity | APBA1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: APBA1 antibody detects endogenous levels of total APBA1. Function: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.Subunit Structure: Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Both isoform 1 and isoform 2 bind to the cytoplasmic domain of amyloid protein (APP). Interacts (via PDZ 1 and 2 domains) with FSPB. Isoform 2, but not isoform 1, interacts (via its truncated PID domain) with active, GTP-bound RAB6A and RAB6B. |
Immunogen | Immunogen: A synthesized peptide derived from human APBA1 Subcellular Location: Nucleus; Golgi Apparatus Tissue Specificity: Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen. Predicted Cross Reactivity: Bovine, Sheep, Rabbit, Dog Similarity: Bovine (86%), Sheep (86%), Rabbit (86%), Dog (93%) |
Other Names | [Adapter protein X11 alpha; Adapter protein X11alpha; Amyloid beta A4 precursor protein-binding family A member 1; Apba1; APBA1_HUMAN; Mint 1; Mint-1; Neuron specific X11 protein; Neuron-specific X11 protein; Neuronal Munc18 1 interacting protein 1; Neuronal Munc18-1-interacting protein 1; UROP11; x11; X11alpha] |
Gene, Accession # | [APBA1], Gene ID: 320, NCBI: NP_001154.2, UniProt: Q02410 |
Catalog # | MBS9609519 |
Price | $240, $280 |
Order / More Info | APBA1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |