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Antigenic Specificity | IL18 binding protein |
Clone | [5C7-D2-G4-B6] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.1 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Entrez Summary: The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses.This protein is constitutively expressed and secreted in mononuclear cells.Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease.Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Feb 2011]. UniPort Summary Function: Isoform A binds to IL-18 and inhibits its activity.Functions as an inhibitor of the early TH1 cytokine response. |
Immunogen | Immunogen: Purified recombinant human IL18 binding protein protein fragments expressed in E Coli. Sensitivity: This antibody detects endogenous levels of IL18 binding protein and does not cross-react with related proteins. Sequence Similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. |
Other Names | [I18BP_HUMAN; IL-18BP; IL18 BP; IL18 BPa; IL18BP; IL18BPa; Interleukin 18 binding protein; Interleukin-18-binding protein; MC51L 53L 54L homolog gene product; Tadekinig alfa; Tadekinig-alfa], [IL18BPa] |
Gene, Accession # | [IL18], Gene ID: 10068, NCBI: NP_001034748.1, UniProt: O95998 |
Catalog # | MBS475009 |
Price | $335 |
Order / More Info | IL18 binding protein Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |