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Antigenic Specificity | IKAP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | IKAP Antibody: IKAP was initially identified as a scaffold protein of the IκB kinase complex that could bind to IKKα, IKKβ, NF-κB, and the NF-κB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) |
Immunogen | Immunogen: IKAP antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human IKAP. Buffer: IKAP Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [IKAP; FD; DYS; ELP1; IKAP; IKI3; TOT1; Elongator complex protein 1; IkappaB kinase complex-associated protein; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein], [IKBKAP; IKBKAP; FD; DYS; ELP1; IKAP; IKI3; TOT1; ELP1; IKAP; ELP1; IKK complex-associated protein] |
Gene, Accession # | [IKBKAP], Gene ID: 8518, NCBI: AAC64258, UniProt: O95163 |
Catalog # | MBS150596 |
Price | $375 |
Order / More Info | IKAP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |